Modulation of Adenine Phosphoribosyltransferase-Mediated Purine Salvage to Accelerate Diabetic Wound Healing

This Medfyle was published more than two years ago. More recent Medfyle on this topic may now be available.

Key messages

• The role of APRT was evaluated in diabetic wound healing in genetically diabetic mice receiving surgery for full-thickness of a cutaneous wound and adenine addition as the substrate for APRT on the wound.
• Up-regulated APRT found in wound skin correlated with the demands of wound repair in diabetic mice, and administration of adenine on the wound of diabetic mice exhibited elevated ATP levels in organismic skin and accelerated wound healing.
• These results highlight the role of APRT during diabetic wound healing by regulating the nucleotide pool after injury and demonstrated the improvement by topical adenine, which highlights its value as a promising agent in therapeutic intervention.